A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase-Reference-Cited by-同舟云学术

A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase

Published:2019 Issue:12 Volume:10 Page:2170-2174
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Beekman Andrew Michael¹²³⁴^ORCID,Cominetti Marco M. D.¹²³⁴,Cartwright Oliver Charles¹²³⁴,Boger Dale L.⁵⁶⁷⁸,Searcey Mark¹²³⁴^ORCID

Affiliation:

1. School of Pharmacy & School of Chemistry

2. University of East Anglia

3. Norfolk

4. UK

5. Department of Chemistry

6. The Scripps Research Institute

7. California 92037

8. USA

Abstract

A SMDC is delivered to GCPII, an important cancer target. The payload is released by enzymes overexpressed in cancer cell lines. The SMDC relies on GCPII expression for efficacy.

Funder

Biotechnology and Biological Sciences Research Council

Novartis Pharma

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00279K

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