A biocompatible photosensitizer with a high intersystem crossing efficiency for precise two-photon photodynamic therapy

Author:

Xu Zhourui1ORCID,Jiang Yihang1ORCID,Shen Yuanyuan1,Tang Lele2,Hu Zulu1,Lin Guimiao3,Law Wing-Cheung4ORCID,Ma Mingze1,Dong Biqin5ORCID,Yong Ken-Tye67ORCID,Xu Gaixia1ORCID,Tao Ye2ORCID,Chen Runfeng2ORCID,Yang Chengbin1

Affiliation:

1. Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, 1066th Xueyuan Rd, Nanshan District, Shenzhen, Guangdong Province, China

2. State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9th Wenyuan Road, Nanjing 210023, China

3. Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Lab of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences, Shenzhen University, 1066th Xueyuan Rd, Nanshan District, Shenzhen, Guangdong Province, China

4. Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, 11th YukChoi Rd, Hong Hum, Kowloon, Hong Kong

5. Guangdong Provincial Key Laboratory of Durability for Marine Civil Engineering, College of Civil and Transportation Engineering, Shenzhen University, 3688th Nanhai Rd, Nanshan District, Shenzhen, Guangdong Province, China

6. School of Biomedical Engineering, The University of Sydney, Sydney, New South Wales 2006, Australia

7. The University of Sydney Nano Institute, The University of Sydney, Sydney, New South Wales 2006, Australia

Abstract

A biocompatible organic room-temperature phosphorescence photosensitizer that can be excited using two-photon near-infrared light is developed for photodynamic therapy to achieve improved oxygen species generation and tissue penetration.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Medical Science and Technology Foundation of Guangdong Province

Shenzhen University

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrical and Electronic Engineering,Process Chemistry and Technology,Mechanics of Materials,General Materials Science

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