Ultrasensitive quantification of tumor mRNAs in extracellular vesicles with an integrated microfluidic digital analysis chip-Reference-Cited by-同舟云学术

Ultrasensitive quantification of tumor mRNAs in extracellular vesicles with an integrated microfluidic digital analysis chip

Published:2018 Issue:24 Volume:18 Page:3790-3801
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Zhang Peng¹²³⁴,Crow Jennifer⁵⁶⁷⁴,Lella Divya¹²³⁴,Zhou Xin¹²³⁴,Samuel Glenson⁸⁹⁷⁴,Godwin Andrew K.⁵⁶⁷⁴¹⁰,Zeng Yong¹²³⁴¹⁰^ORCID

Affiliation:

1. Department of Chemistry

2. University of Kansas

3. Lawrence

4. USA

5. Department of Pathology and Laboratory Medicine

6. University of Kansas Medical Center

7. Kansas City

8. Division of Hematology Oncology and Bone Marrow Transplantation

9. Children's Mercy Hospitals & Clinics

10. University of Kansas Cancer Center

Abstract

A microwell-patterned microfluidic digital mRNA analysis platform enables PCR-free, single-molecule detection of EWS-FLI1 fusion transcripts in EVs towards liquid biopsy-based non-invasive diagnosis of Ewing Sarcoma.

Funder

National Institute of General Medical Sciences

National Cancer Institute

National Institute of Biomedical Imaging and Bioengineering

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2018/LC/C8LC01071D

Reference67 articles.

1. Are liquid biopsies a surrogate for tissue EGFR testing?

2. Real-time Liquid Biopsy in Cancer Patients: Fact or Fiction?

3. Liquid biopsy: monitoring cancer-genetics in the blood

4. Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes

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