Ultrasensitive quantification of tumor mRNAs in extracellular vesicles with an integrated microfluidic digital analysis chip

Author:

Zhang Peng1234,Crow Jennifer5674,Lella Divya1234,Zhou Xin1234,Samuel Glenson8974,Godwin Andrew K.567410,Zeng Yong123410ORCID

Affiliation:

1. Department of Chemistry

2. University of Kansas

3. Lawrence

4. USA

5. Department of Pathology and Laboratory Medicine

6. University of Kansas Medical Center

7. Kansas City

8. Division of Hematology Oncology and Bone Marrow Transplantation

9. Children's Mercy Hospitals & Clinics

10. University of Kansas Cancer Center

Abstract

A microwell-patterned microfluidic digital mRNA analysis platform enables PCR-free, single-molecule detection of EWS-FLI1 fusion transcripts in EVs towards liquid biopsy-based non-invasive diagnosis of Ewing Sarcoma.

Funder

National Institute of General Medical Sciences

National Cancer Institute

National Institute of Biomedical Imaging and Bioengineering

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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