Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease-Reference-Cited by-同舟云学术

Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease

Published:2023 Issue:82 Volume:59 Page:12306-12309
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Kato Izumi¹²,Ogawa Yudai¹,Yakushiji Fumika¹³,Ogura Jiro⁴,Kobayashi Masaki²,Shindo Naoya¹⁵^ORCID,Ichikawa Satoshi¹³^ORCID,Maenaka Katsumi¹³⁵⁶⁷^ORCID,Sakaitani Masahiro¹

Affiliation:

1. Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan

2. Education Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan

3. Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Sapporo 060-0812, Japan

4. Department of Pharmacy, Yamagata University Hospital, 2-2-2 Iida-Nishi, Yamagata-shi, Yamagata 990-9585, Japan

5. Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

6. Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan

7. Division of Pathogen Structure, International Institute for Zoonosis Control, Hokkaido University, Sapporo 060-0812, Japan

Abstract

A new compound, a derivative of 3,4,5-trimethoxy-N-phenyl benzamide bearing an 8′′-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress.

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Japan Agency for Medical Research and Development

Hokkaido University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC03069E

Reference13 articles.

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2. Balance is the challenge - The impact of mitochondrial dynamics in Parkinson’s disease

3. The α-Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy

4. A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine–acetylcholine synaptic balance