Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication-Reference-Cited by-同舟云学术

Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication

Published:2015 Issue:18 Volume:13 Page:5158-5174
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Maiti Munmun¹²³⁴⁵,Maiti Mohitosh¹²³⁴⁵,Rozenski Jef¹²³⁴⁵,De Jonghe Steven¹²³⁴⁵,Herdewijn Piet¹²³⁴⁵

Affiliation:

1. Rega Institute for Medical Research

2. Medicinal Chemistry

3. KU Leuven

4. 3000 Leuven

5. Belgium

Abstract

A series of novel nucleoside phosphoramidate protides has been synthesized and shown as potent inhibitors of hepatitis C virus replication. The conjugates are having a diverse structural variation in the promoiety part and can be catalytically processed to deliver active nucleotides.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00427F

Reference43 articles.

1. http://www.who.int/en/

2. Prevalence and Challenges of Liver Diseases in Patients With Chronic Hepatitis C Virus Infection

3. Peginterferon and Ribavirin for Chronic Hepatitis C

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