A refined phase diagram of the tert-butanol–water system and implications on lyophilization process optimization of pharmaceuticals-Reference-Cited by-同舟云学术

A refined phase diagram of the tert-butanol–water system and implications on lyophilization process optimization of pharmaceuticals

Published:2020 Issue:3 Volume:22 Page:1583-1590
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Bhatnagar Bakul S.¹²³⁴⁵,Sonje Jayesh¹²³⁴⁵^ORCID,Shalaev Evgenyi⁶⁷⁸⁹⁵,Martin Susan W. H.¹⁰¹¹⁵,Teagarden Dirk L.¹⁰¹¹⁵,Suryanarayanan Raj¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutics, College of Pharmacy

2. 308 Harvard St. SE

3. University of Minnesota

4. Minneapolis

5. USA

6. Pfizer Groton Laboratories

7. Eastern Point Road

8. Pfizer Inc.

9. Groton

10. Pfizer Biotherapeutics, Pfizer Inc.

11. St. Louis

Abstract

In TBA–water mixtures, using DSC and XRD, the eutectic temperature (−8 °C) and composition (22.5% w/w TBA) were determined.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CP/C9CP06576H

Reference18 articles.

1. M. J. Pikal , Freeze Drying , in Encyclopedia of Pharmaceutical Technology , ed. J. Swarbrick , Informa Healthcare USA, Inc. , 2006 , pp. 1807–1833

2. Practical aspects of lyophilization using non-aqueous co-solvent systems

3. Crystallization of Cephalothin Sodium During Lyophilization from tert-Butyl Alcohol?Water Cosolvent System

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