Exploring resistance mechanisms of HCV NS3/4A protease mutations to MK5172: insight from molecular dynamics simulations and free energy calculations
Author:
Affiliation:
1. College of Pharmaceutical Sciences
2. Zhejiang University
3. Hangzhou
4. China
5. Institute of Functional Nano & Soft Materials (FUNSOM)
6. Soochow University
7. Suzhou
Abstract
Mutations at a number of key positions (Ala156, Asp168 and Arg155) of the HCV NS3/4A protease can induce medium to high resistance to MK5172.
Publisher
Royal Society of Chemistry (RSC)
Subject
Molecular Biology,Biotechnology
Link
http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00394F
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