Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines-Reference-Cited by-同舟云学术

Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines

Published:2021 Issue:2 Volume:6 Page:220-224
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Guidi Mara¹²³⁴⁵^ORCID,Moon Sooyeon¹²³⁴⁵^ORCID,Anghileri Lucia¹²³⁴⁵,Cambié Dario¹²³⁴^ORCID,Seeberger Peter H.¹²³⁴⁵^ORCID,Gilmore Kerry¹²³⁴⁶^ORCID

Affiliation:

1. Department of Biomolecular Systems

2. Max Planck Institute of Colloids and Interfaces

3. 14476 Potsdam

4. Germany

5. Department of Chemistry and Biochemistry

6. University of Connecticut

Abstract

Rapid, standardized process optimization and development on a radial synthesizer can be directly converted to a dedicated continuous flow process for scale-up, shown for three APIs via single- and multistep syntheses and continuous crystallization.

Funder

Deutsche Forschungsgemeinschaft

Max-Planck-Gesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RE/D0RE00445F

Reference18 articles.

1. How to address medicines shortages: Findings from a cross-sectional study of 24 countries

2. Sustainable flow approaches to active pharmaceutical ingredients

3. The Hitchhiker’s Guide to Flow Chemistry

4. The Molecular Industrial Revolution: Automated Synthesis of Small Molecules

5. A robotic platform for flow synthesis of organic compounds informed by AI planning

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Production of Biomass‐Derived p‐Hydroxybenzamide: Synthesis of p‐Aminophenol and Paracetamol;ChemSusChem;2024-04-22

2. Doing More with Less, On Time and In Full: An Intelligent Multiattribute Process Optimization Platform;Organic Process Research & Development;2024-02-26

3. Efficient construction of a β-naphthol library under continuous flow conditions;RSC Advances;2024

4. Assembly Line Library Synthesis in Flow: A Multistep and Multivectorial Approach;2024

5. Flow chemical laboratory practice for undergraduate students: synthesis of paracetamol;Journal of Flow Chemistry;2023-12-27