Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines
Author:
Affiliation:
1. Department of Biomolecular Systems
2. Max Planck Institute of Colloids and Interfaces
3. 14476 Potsdam
4. Germany
5. Department of Chemistry and Biochemistry
6. University of Connecticut
Abstract
Rapid, standardized process optimization and development on a radial synthesizer can be directly converted to a dedicated continuous flow process for scale-up, shown for three APIs via single- and multistep syntheses and continuous crystallization.
Funder
Deutsche Forschungsgemeinschaft
Max-Planck-Gesellschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2021/RE/D0RE00445F
Reference18 articles.
1. How to address medicines shortages: Findings from a cross-sectional study of 24 countries
2. Sustainable flow approaches to active pharmaceutical ingredients
3. The Hitchhiker’s Guide to Flow Chemistry
4. The Molecular Industrial Revolution: Automated Synthesis of Small Molecules
5. A robotic platform for flow synthesis of organic compounds informed by AI planning
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