Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch-Reference-Cited by-同舟云学术

Enone-promoted decarboxylation of trans-4-hydroxy-l-proline in flow: a side-by-side comparison to batch

Published:2021 Issue:3 Volume:6 Page:486-493
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Pilkington Rowan L.¹²³⁴^ORCID,Dallaston Madeleine A.⁵⁶⁷⁴^ORCID,Savage G. Paul⁸⁹³⁴,Williams Craig M.⁵⁶⁷⁴^ORCID,Polyzos Anastasios¹²³⁴⁸^ORCID

Affiliation:

1. School of Chemistry

2. The University of Melbourne

3. Melbourne

4. Australia

5. School of Chemistry and Molecular Biosciences

6. University of Queensland

7. Brisbane

8. Ian Wark Laboratory

9. CSIRO Manufacturing

Abstract

An efficient and scalable enone-promoted method for the decarboxylation of trans-4-hydroxy-proline has been developed in flow to provide access to (R)-pyrrolidin-3-ol hydrochloride using biomass-derived isophorone.

Funder

Australian Research Council

University of Queensland

University of Melbourne

Commonwealth Scientific and Industrial Research Organisation

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RE/D0RE00442A

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