Switching the proton-coupled electron transfer mechanism for non-canonical tyrosine residues in a <i>de novo</i> protein-Reference-Cited by-同舟云学术

Switching the proton-coupled electron transfer mechanism for non-canonical tyrosine residues in a de novo protein

Published:2024 Issue:11 Volume:15 Page:3957-3970
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Nilsen-Moe Astrid¹,Reinhardt Clorice R.²^ORCID,Huang Ping¹^ORCID,Agarwala Hemlata³,Lopes Rosana⁴^ORCID,Lasagna Mauricio⁴^ORCID,Glover Starla¹,Hammes-Schiffer Sharon⁵^ORCID,Tommos Cecilia⁴^ORCID,Hammarström Leif¹^ORCID

Affiliation:

1. Department of Chemistry, Ångström Laboratory, Uppsala University, Box 523, 75120 Uppsala, Sweden

2. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA

3. Technical University Munich, Campus Straubing for Biotechnology and Sustainability, Uferstraße 53, 94315 Straubing, Germany

4. Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA

5. Department of Chemistry, Yale University, New Haven, CT 06520, USA

Abstract

Proton-coupled electron transfer reactions of tyrosine are instrumental to many redox reactions in nature. By balancing the driving forces for electron and proton transfer, the mechanism can be changed from step-wise to concerted transfer (CEPT).

Funder

National Science Foundation Graduate Research Fellowship Program

National Institutes of Health

Vetenskapsrådet

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC05450K

Reference49 articles.

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