Synthesis of 1,4-diazepinone derivatives via a domino aza-Michael/SN2 cyclization of 1-azadienes with α-halogenoacetamides-Reference-Cited by-同舟云学术

Synthesis of 1,4-diazepinone derivatives via a domino aza-Michael/SN2 cyclization of 1-azadienes with α-halogenoacetamides

Published:2020 Issue:6 Volume:18 Page:1082-1086
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yuan Chunhao¹²³⁴^ORCID,Zhang Hui¹²³⁴,Yuan Mengna¹²³⁴,Xie Lei⁵⁶⁷⁴,Cao Xiaoqun¹²³⁴

Affiliation:

1. School of Chemistry and Pharmaceutical Engineering

2. Shandong First Medical University & Shandong Academy of Medical Sciences

3. Taian 271016

4. P. R. China

5. School of Pharmacy

6. Liaocheng University

7. Liaocheng 252000

Abstract

A novel cyclization of N-alkoxy α-halogenoacetamides with N-sulfonyl-1-aza-1,3-butadienes has been developed for the efficient preparation of 1,4-diazepinones in one step under transition metal-free conditions.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02626F

Reference75 articles.

1. Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

2. Synthesis and biological evaluation of novel 6,11-dihydro-5 H -benzo[e]pyrimido- [5,4- b ][1,4]diazepine derivatives as potential c-Met inhibitors

3. 1,4-Diazepane-2-ones as novel inhibitors of LFA-1

4. Nucleoside antibiotics: Structure, biological activity, and biosynthesis.

5. Synthesis of Caprazamycin Analogues and Their Structure−Activity Relationship for Antibacterial Activity

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Construction of 1,4‐Oxazepinones via a Cascade Aza‐Michael/S_N2 Annulation of Trifluoromethyl Pyrazole‐Derived Oxadienes with a‐Bromohydroxamates;Asian Journal of Organic Chemistry;2024-08-21

2. Lewis base-catalyzed [3 + 2] annulation of β-oxo-acrylamides with acyl isothiocyanates: facile access to 2-iminothiazolidin-4-one derivatives;Tetrahedron Letters;2024-04

3. Synthesis of Polycyclic Imidazolidinones via Cascade [3 + 2]-Annulation of β-Oxo-acrylamides with Cyclic N-Sulfonyl Imines;The Journal of Organic Chemistry;2023-10-31

4. Base-Promoted Formal (3 + 2) Cycloaddition of α-Halohydroxamates with Electron-Deficient Alkenyl-iminoindolines To Synthesize Spiro-indolinepyrrolidinones;The Journal of Organic Chemistry;2023-10-04

5. [8+2]‐Cycloaddition Reaction of Carbamates and N‐Sulfonyl azaheptafulvenes;ChemistrySelect;2023-08-16