Development of novel triazole based dendrimer supported spiroborate chiral catalysts for the reduction of (E)-O-benzyl oxime: an enantioselective synthesis of (S)-dapoxetine

Abstract

A reusable dendrimer supported spiroborate catalysts 2 and 3 have been synthesized via a “click” chemistry and demonstrated as catalysts for the reduction of (E)-O-benzyl oxime 13 to synthesis of (S)-dapoxetine 14 with 94% ee and 46% overall yield.