NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications

Author:

Jiang Chenyang1234,Huang Haojie1234,Kang Xueying1234,Yang Liu5674,Xi Zhen89101112,Sun Hongyan567413ORCID,Pluth Michael D.1415161718ORCID,Yi Long1234ORCID

Affiliation:

1. State Key Laboratory of Organic–Inorganic Composites and Beijing Key Lab of Bioprocess

2. Beijing University of Chemical Technology (BUCT)

3. Beijing 100029

4. China

5. Department of Chemistry and Center of Super-Diamond and Advanced Films (COSDAF)

6. City University of Hong Kong

7. Kowloon

8. State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology

9. College of Chemistry

10. National Pesticide Engineering Research Center

11. Collaborative Innovation Center of Chemical Science and Engineering

12. Nankai University

13. Key Laboratory of Biochip Technology

14. Department of Chemistry and Biochemistry

15. Materials Science Institute

16. Knight Campus for Accelerating Scientific Impact

17. Institute of Molecular Biology

18. University of Oregon

Abstract

Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit high reactivity toward biological nucleophilies accompanied by distinct colorimetric and fluorescent changes, environmental sensitivity, and small size, all of which facilitate biomolecular sensing and self-assembly.

Funder

National Key Research and Development Program of Chin

National Natural Science Foundation of China

National Institutes of Health

Natural Science Foundation of Beijing Municipality

Shenzhen Science and Technology Innovation Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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