Tetrazine-induced activation of a trimethyl lock as a click-to-release system for protected doxorubicin-Reference-Cited by-同舟云学术

Tetrazine-induced activation of a trimethyl lock as a click-to-release system for protected doxorubicin

Published:2023 Issue:48 Volume:59 Page:7451-7454
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Friederich Julia¹,Xu Chunfa¹²^ORCID,Raunft Patrick¹^ORCID,Fuchs Hazel L. S.¹^ORCID,Brönstrup Mark¹³⁴^ORCID

Affiliation:

1. Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstraße 7, Braunschweig 38124, Germany

2. Institute of Pharmaceutical Science and Technology, College of Chemistry, Fuzhou University, Fuzhou 350108, China

3. Biomolecular Drug Research Center (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, Hannover 30167, Germany

4. German Center for Infection Research (DZIF), Site Hannover-Braunschweig, Inhoffenstraße 7, Braunschweig 38124, Germany

Abstract

A novel click-to-release system enabling the chemically triggered activation of doxorubicin by combining an inverse electron demand Dials–Alder reaction with a trimethyl lock was synthesized and characterized.

Funder

Deutsches Zentrum für Infektionsforschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC01334K

Reference22 articles.

1. The expanding role of prodrugs in contemporary drug design and development

2. Prodrug strategy for cancer cell-specific targeting: A recent overview

3. Prodrugs in medicinal chemistry and enzyme prodrug therapies

4. Prodrug Strategies Based on Intramolecular Cyclization Reactions

5. Selective Bacterial Targeting and Infection‐Triggered Release of Antibiotic Colistin Conjugates

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