Sterol A-ring plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity mechanism-Reference-Cited by-同舟云学术

Sterol A-ring plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity mechanism

Published:2019 Issue:12 Volume:55 Page:1829-1832
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ciulla Daniel A.¹²³,Wagner Andrew G.¹²³,Liu Xinyue⁴⁵⁶⁷³,Cooper Courtney L.¹²³,Jorgensen Michael T.⁸⁹³,Wang Chunyu⁴⁵⁶⁷³^ORCID,Goyal Puja¹²³,Banavali Nilesh K.¹⁰¹¹³,Pezzullo John L.⁸⁹³,Giner José-Luis⁸⁹³,Callahan Brian P.¹²³^ORCID

Affiliation:

1. Chemistry Department, Binghamton University

2. Binghamton

3. USA

4. Department of Biological Sciences

5. Center for Biotechnology and Interdisciplinary Studies

6. Rensselaer Polytechnic Institute

7. Troy

8. Department of Chemistry, SUNY-ESF

9. Syracuse

10. NYS Department of Health, ESP C419B, Biggs Laboratory, Wadsworth Center, Empire State Plaza

11. Albany

Abstract

The enzymatic agent of hedgehog protein cholesterolysis accommodates substrate sterols with undersized, oversized and distorted ring systems relative to cholesterol.

Funder

National Cancer Institute

U.S. Department of Defense

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C8CC09729A

Reference31 articles.

1. Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

2. Mutations in the C-Terminal Domain of Sonic Hedgehog Cause Holoprosencephaly

3. Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction

4. The Sonic Hedgehog Receptor Patched Associates with Caveolin-1 in Cholesterol-rich Microdomains of the Plasma Membrane

5. Novel Lipid Modifications of Secreted Protein Signals

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Hedgehog Autoprocessing: From Structural Mechanisms to Drug Discovery;Frontiers in Molecular Biosciences;2022-05-20

2. Enzymatic Beacons for Specific Sensing of Dilute Nucleic Acid**;ChemBioChem;2021-12-29

3. Enzymatic Beacons for Specific Sensing of Dilute Nucleic Acid and Potential Utility for SARS-CoV-2 Detection;2021-08-31

4. Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis;Biochemistry;2020-02-04

5. Non-canonical lipoproteins with programmable assembly and architecture;Chemical Communications;2020