Design, synthesis and evaluation of (R)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-5-azaspiro[2.4]heptan-5-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor-Reference-Cited by-同舟云学术

Design, synthesis and evaluation of (R)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-5-azaspiro[2.4]heptan-5-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor

Published:2018 Issue:3 Volume:9 Page:477-489
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Chough Chieyeon¹²³⁴⁵^ORCID,Lee Sunmin⁶⁷⁸⁵^ORCID,Joung Misuk⁶⁷⁸⁵^ORCID,Lee Jaemin⁶⁷⁸⁵^ORCID,Kim Jong Hoon⁹¹⁰⁵^ORCID,Kim B. Moon¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. College of Natural Sciences

3. Seoul National University

4. Seoul 08876

5. South Korea

6. Yang Ji Chemical Co., Ltd.

7. Gyeonggi Bio-Center

8. Suwon

9. Han Wha Pharma Co., Ltd.

10. Chuncheon

Abstract

We discovered a new JAK1-selective inhibitor with a selectivity index of 48 and identified its efficacy in CIA and AIA models.

Funder

National Research Foundation of Korea

Ministry of Science, ICT and Future Planning

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C7MD00568G

Reference50 articles.

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