Structure and surface analyses of a newly synthesized acyl thiourea derivative along with its <i>in silico</i> and <i>in vitro</i> investigations for RNR, DNA binding, urease inhibition and radical scavenging activities-Reference-Cited by-同舟云学术

Structure and surface analyses of a newly synthesized acyl thiourea derivative along with its in silico and in vitro investigations for RNR, DNA binding, urease inhibition and radical scavenging activities

Published:2022 Issue:27 Volume:12 Page:17194-17207
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Khalid Aqsa¹,Arshad Nasima²^ORCID,Channar Pervaiz Ali¹^ORCID,Saeed Aamer¹^ORCID,Mir Muhammad Ismail²^ORCID,Abbas Qamar³,Ejaz Syeda Abida⁴,Hökelek Tuncer⁵,Saeed Amna⁴^ORCID,Tehzeeb Arfa¹

Affiliation:

1. Department of Chemistry, Quaid-i-Azam University, 45320, Islamabad, Pakistan

2. Department of Chemistry, Allama Iqbal Open University, 44000, Islamabad, Pakistan

3. Department of Biology, College of Science, University of Bahrain, Sakhir Campus, 32038, Bahrain

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan

5. Department of Physics, Faculty of Engineering, Hacettepe University, Beytepe-Ankara, 06800, Turkey

Abstract

A new acyl thiourea derivative was explored for its binding interaction with RNR and DNA and for excellent urease inhibition activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA03160D

Reference55 articles.

1. Thiourea and Guanidine Derivatives as Antimalarial and Antimicrobial Agents^§

2. Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agents

3. Recent trends in chemistry, structure, and various applications of 1-acyl-3-substituted thioureas: a detailed review

4. Novel flexible heteroarotinoid, SL-1-18, promotes ERα degradation to inhibit breast cancer cell growth

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