The proximity-enabled sulfur fluoride exchange reaction in the protein context-Reference-Cited by-同舟云学术

The proximity-enabled sulfur fluoride exchange reaction in the protein context

Published:2023 Issue:29 Volume:14 Page:7913-7921
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yu Bingchen¹^ORCID,Cao Li¹,Li Shanshan¹,Klauser Paul C.¹^ORCID,Wang Lei¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, The Cardiovascular Research Institute, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, 555 Mission Bay Blvd. South, San Francisco, California 94158, USA

Abstract

Proximity-enabled SuFEx reaction between interacting proteins was found to follow a two-step mechanism. Kinetics and essential properties were thoroughly studied for SuFEx applications in protein cross-linking and covalent biotherapeutics.

Funder

National Cancer Institute

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01921G

Reference47 articles.

1. The growing applications of SuFEx click chemistry

2. Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry