Structural characterisation of amyloid-like fibrils formed by an amyloidogenic peptide segment of β-lactoglobulin

Author:

Gowda Vasantha1ORCID,Biler Michal2ORCID,Filippov Andrei34ORCID,Mantonico Malisa V.1,Ornithopoulou Eirini1,Linares Mathieu256,Antzutkin Oleg N.37ORCID,Lendel Christofer1ORCID

Affiliation:

1. Dept. of Chemistry, KTH Royal Institute of Technology, Stockholm, Sweden

2. Dept. of Theoretical Chemistry, KTH Royal Institute of Technology, Stockholm, Sweden

3. Chemistry of Interfaces, Luleå University of Technology, Sweden

4. Dept. Medical and Biological Physics, Kazan State Medical University, 420012, Kazan, Russia

5. Laboratory of Organic Electronics and Group of Scientific Visualization, ITN, Linköping University, 60174 Norrköping, Sweden

6. Swedish e-Science Research Centre (SeRC), Linköping University, 60174 Norrköping, Sweden

7. Dept. of Physics, University of Warwick, Coventry, UK

Abstract

A 10-residue peptide segment of β-lactoglobulin (β-LG11–20) forms amyloid-like fibrils as revealed by AFM, NMR, and MD simulations.

Funder

Carl Tryggers Stiftelse för Vetenskaplig Forskning

Swedish e-Science Research Centre

Kempe Foundations

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference65 articles.

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5. Islet Amyloid and Type 2 Diabetes Mellitus

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