Syntheses of defined sulfated oligohyaluronans reveal structural effects, diversity and thermodynamics of GAG

Syntheses of defined sulfated oligohyaluronans reveal structural effects, diversity and thermodynamics of GAG–protein binding

Published:2019 Issue:3 Volume:10 Page:866-878
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Köhling Sebastian¹²³⁴,Blaszkiewicz Joanna¹²³⁴,Ruiz-Gómez Gloria⁵⁶⁷⁴,Fernández-Bachiller María Isabel¹²³⁴,Lemmnitzer Katharina⁸⁹¹⁰⁴,Panitz Nydia¹¹⁹¹²⁴,Beck-Sickinger Annette G.¹¹⁹¹²⁴,Schiller Jürgen⁸⁹¹⁰⁴^ORCID,Pisabarro M. Teresa⁵⁶⁷⁴,Rademann Jörg¹²³⁴^ORCID

Affiliation:

1. Institute of Pharmacy – Medicinal Chemistry

2. Freie Universität Berlin

3. 14195 Berlin

4. Germany

5. Structural Bioinformatics

6. BIOTEC TU Dresden

7. Dresden 01307

8. Institute of Medical Physics and Biophysics

9. University of Leipzig

10. 04107 Leipzig

11. Institute of Biochemistry

12. 04103 Leipzig

Abstract

High binding affinities of GAG toward extracellular regulatory proteins are governed by recognition diversity, sulfation pattern, length, and anomeric functionalization.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC03649G

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