Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2)-Reference-Cited by-同舟云学术

Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2)

Published:2016 Issue:2 Volume:14 Page:747-751
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhan Yang¹²³⁴⁵,Zhang Xiao-Wei⁶⁷⁸⁴⁵,Xiong Ying⁶⁷⁸⁴⁵,Li Bo-Liang⁶⁷⁸⁴⁵,Nan Fa-Jun¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Drug Research

2. The National Center for Drug Screening

3. Shanghai Institute of Materia Medica

4. Chinese Academy of Sciences

5. Shanghai

6. State Key Laboratory of Molecular Biology

7. Institute of Biochemistry and Cell Biology

8. Shanghai Institutes for Bio-logical Sciences

Abstract

A series of pyripyropene A-based compounds were designed and synthesized by opening the upper section of the A-ring, which significantly simplifies the structure and synthesis from commercially available starting materials.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02019K

Reference28 articles.

1. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice

2. ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: Impact on hepatic cholesterol homeostasis

3. ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice

4. 3 ACAT Inhibitors: The Search for a Novel and Effective Treatment of Hypercholesterolemia and Atherosclerosis

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Transcriptome Response to Azole Compounds in Aspergillus fumigatus Shows Differential Gene Expression across Pathways Essential for Azole Resistance and Cell Survival;Journal of Fungi;2023-07-30

2. Targeting Sterol O-Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential;Journal of Medicinal Chemistry;2022-12-06

3. Construction of three stereocenters via hydrogenative desymmetrization of 2,2,5-trisubstituted cyclohexane-1,3-diones;Science China Chemistry;2020-12-11

4. Design and synthesis of further simplified pyripyropene A based ACAT2 selective inhibitors;Tetrahedron;2019-03

5. Asymmetric Synthesis of Novel Fused Polycyclic 3,4-Dihydro-pyrano[4,3-b]pyran-5(2H)-ones via an Organocatalyzed Formal[3+3] Annulation;Chinese Journal of Organic Chemistry;2019