Design, synthesis and evaluation of a myricetin and nobiletin hybrid compound for alleviating hyperuricemia based on metabolomics and gut microbiota-Reference-Cited by-同舟云学术

Design, synthesis and evaluation of a myricetin and nobiletin hybrid compound for alleviating hyperuricemia based on metabolomics and gut microbiota

Published:2023 Issue:31 Volume:13 Page:21448-21458
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Li Yan¹²³^ORCID,Pu Liu-Yang¹³^ORCID,Li Yayun⁴,Zhu Guanbao⁵,Wu Zhengzhi¹²³

Affiliation:

1. Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518035, China

2. Wu Zhengzhi Academician Workstation, NingBo College of Health Sciences, Ningbo 315800, China

3. Shenzhen Institute of Geriatrics, Shenzhen 518035, China

4. Hunan University of Chinese Medicine, Changsha 410208, China

5. Guangxi University of Chinese Medicine, Nanning 530200, China

Abstract

A hybrid compound consisting of myricetin and nobiletin (MNH) was designed and synthesized, which might represent a protective effect against HUA via modulating the gut microbiota composition and serum metabolite profile.

Funder

National Natural Science Foundation of China

Shenzhen Science and Technology Innovation Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA03188H

Reference44 articles.

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