Reduction-responsive polymeric micelles for trans-corneal targeted delivery of microRNA-21-5p and glaucoma-specific gene therapy

Author:

Han Binze1ORCID,Zhang Rong1,Li Liping1,Hu Chunchun1,Li Mengwei1,Liu Jiamin1,Sun Xinghuai12,Fan Wenpei3ORCID,Xie Jinbing4,Lei Yuan12ORCID

Affiliation:

1. Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China

2. NHC Key Laboratory of Myopia, Chinese Academy of Medical Sciences, and Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai 200031, China

3. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, P. R. China

4. Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, P. R. China

Abstract

A biocompatible polymeric poly(l-lysine) (PLL) micelle conjugated with collagenase and ABCA1 antibody was constructed to achieve trans-corneal and target delivery of miR-21-5p to the trabecular meshwork (TM) and Schlemm's canal (SC).

Funder

Natural Science Foundation of Shanghai Municipality

National Key Research and Development Program of China

National Natural Science Foundation of China

Fudan University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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