Total synthesis and cytotoxicity evaluation of the spirostanol saponin gitonin

Author:

Li Yong12,Lv Xun3,Liu Jun124ORCID,Du Yuguo124

Affiliation:

1. State Key Laboratory of Environmental Chemistry and Eco-toxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China

2. School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

3. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

4. Binzhou Institute of Technology, Weiqiao-UCAS Science and Technology Park, Binzhou 256606, Shandong Province, China

Abstract

We have successfully developed an efficient approach for the first synthesis of gitonin from tigogenin. In a preliminary MTT bioassay, gitonin and structural analogues showed potent antiproliferative activities against A549, HepG2, and MCF-7 cell lines.

Funder

Chinese Academy of Sciences

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

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