Synthesis, antioxidant and antitumoral activity of new 5′-arylchalcogenyl-3′-<i>N</i>-(<i>E</i>)-feruloyl-3′, 5′-dideoxy-amino-thymidine (AFAT) derivatives-Reference-Cited by-同舟云学术

Synthesis, antioxidant and antitumoral activity of new 5′-arylchalcogenyl-3′-N-(E)-feruloyl-3′, 5′-dideoxy-amino-thymidine (AFAT) derivatives

Published:2022 Issue:46 Volume:46 Page:22306-22313
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Leal Julliano G.¹^ORCID,Piccoli Bruna Candia²,Oliveira Cláudia Sirlene²,D’Avila da Silva Fernanda²,Omage Folorunsho Bright²,Rocha João Batista Teixeira da²^ORCID,Sonego Mariana Souza³,Segatto Natália Vieira³,Seixas Fabiana Kommling³,Collares Tiago Veiras³,da Silva Rafael Santos¹,Sarturi Joelma Menegazzi¹,Dornelles Luciano¹^ORCID,Faustino Maria Amparo F.⁴^ORCID,Rodrigues Oscar E. D.¹^ORCID

Affiliation:

1. Department of Chemistry, LabSelen-NanoBio, Federal University of Santa Maria, CEP 97105-900, Santa Maria, RS, Brazil

2. Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil

3. Technological Development Center, Cancer Biotechnology Laboratory, Federal University of Pelotas, Pelotas, RS, Brazil

4. LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal

Abstract

A new multitarget arylchalcogenyl zidovudine derivative is disclosed. The compounds showed a prominent antioxidant and antitumoral activity with no overt sign of toxicity for in vivo evaluations.

Funder

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ03487E

Reference60 articles.

1. Pentafluorosulfanyl group: an emerging tool in optoelectronic materials