Conservation of the enzyme-like activity and biocompatibility of CeO2 nanozymes in simulated body fluids

Author:

Zeng Muling1,Zhang Xu1,Tang Jie1,Liu Xingfei1,Lin Yichao1,Guo Dongdong1,Zhang Yuping1,Ju Shijie1,Fernández-Varo Guillermo234,Wang Ya-Chao5ORCID,Zhou Xiangyu6ORCID,Casals Gregori2347ORCID,Casals Eudald1ORCID

Affiliation:

1. School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China

2. Biochemistry and Molecular Genetics Department, Hospital Clínic of Barcelona, Barcelona 08036, Spain

3. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

4. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain

5. The Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518035, China

6. Obstetrics and Gynecology Hospital of Fudan University, Shanghai Medical College, State Key Lab of Genetic Engineering, Fudan University, Shanghai 200011, China

7. Department of Fundamental Care and Medical-Surgical Nursing, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona 08007, Spain

Abstract

CeO2 nanozymes dispersed for 7 days in simulated body fluids maintain excellent biocompatibility and antioxidant properties. This work provides an experimental basis to explain their in vivo therapeutic effectiveness against chronic inflammation.

Funder

European Regional Development Fund

Instituto de Salud Carlos III

Wuyi University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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