Overexpression of the mitochondrial Mg channel MRS2 increases total cellular Mg concentration and influences sensitivity to apoptosis-Reference-Cited by-同舟云学术

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Overexpression of the mitochondrial Mg channel MRS2 increases total cellular Mg concentration and influences sensitivity to apoptosis

Published:2018 Issue:7 Volume:10 Page:917-928
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Merolle Lucia¹²³^ORCID,Sponder Gerhard⁴⁵⁶⁷,Sargenti Azzurra⁸⁹¹⁰¹¹¹²^ORCID,Mastrototaro Lucia⁸⁹¹⁰¹¹¹²,Cappadone Concettina¹³¹⁴¹⁵³^ORCID,Farruggia Giovanna¹³¹⁴¹⁵³¹⁶^ORCID,Procopio Alessandra¹³¹⁴¹⁵³,Malucelli Emil¹³¹⁴¹⁵³^ORCID,Parisse Pietro¹⁷¹⁸³^ORCID,Gianoncelli Alessandra¹⁷¹⁸³^ORCID,Aschenbach Jörg R.⁴⁵⁶⁷^ORCID,Kolisek Martin¹⁹²⁰²¹²²²³^ORCID,Iotti Stefano¹³¹⁴¹⁵³¹⁶^ORCID

Affiliation:

1. Transfusion Medicine Unit

2. Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia

3. Italy

4. Institute of Veterinary Physiology

5. Freie Universität Berlin

6. Berlin 14163

7. Germany

8. Institute for Clinical Diabetology

9. German Diabetes Center

10. Leibniz Center for Diabetes Research

11. Heinrich Heine University

12. Düsseldorf

13. Department of Pharmacy and Biotechnology

14. University of Bologna

15. Bologna 40127

16. National Institute of Biostructures and Biosystems

17. ELETTRA–Sincrotrone Trieste S.C.p.A.

18. Trieste

19. Biomedical Center Martin

20. Dpt. of Neurosciences

21. Jessenius Faculty of Medicine in Martin at Comenius University Bratislava

22. 03601 Martin

23. Slovakia

Abstract

Mitochondrial Mg channel MRS2 overexpression influences Mg concentration and sensitivity to apoptosis.

Funder

Deutsche Forschungsgemeinschaft

Università di Bologna

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MT/C8MT00050F

Reference53 articles.

1. Magnesium in Man: Implications for Health and Disease

2. Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

3. Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress

4. PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases

5. Low Brain Intracellular Free Magnesium in Mitochondrial Cytopathies

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1. MRS2 missense variation at Asp216 abrogates inhibitory Mg²⁺ binding, potentiating cell migration and apoptosis resistance;Protein Science;2024-07-11

2. N-Glycosylation of MRS2 balances aerobic and anaerobic energy production by reducing rapid mitochondrial Mg²⁺influx in conditions of high glucose or impaired respiratory chain function;2024-07-10

3. Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca2+ uptake and viability;Mitochondrion;2024-05

4. Molecular basis of Mg2+ permeation through the human mitochondrial Mrs2 channel;Nature Communications;2023-08-05

5. Impact of Sample Preparation Methods on Single-Cell X-ray Microscopy and Light Elemental Analysis Evaluated by Combined Low Energy X-ray Fluorescence, STXM and AFM;Molecules;2023-02-20

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