Role of arsenic (+3 oxidation state) methyltransferase in arsenic mediated APL treatment: anin vitroinvestigation-Reference-Cited by-同舟云学术

Role of arsenic (+3 oxidation state) methyltransferase in arsenic mediated APL treatment: anin vitroinvestigation

Published:2018 Issue:6 Volume:10 Page:828-837
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Maimaitiyiming Yasen¹²³⁴,Wang Chao⁵⁶²³⁴,Xu Shi⁷²³⁴,Islam Khairul¹²³⁴⁵,Chen Ye Jia⁵⁶²³⁴,Yang Chang¹²³⁴,Wang Qian Qian⁵⁶²³⁴,Naranmandura Hua¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmacology, School of Medicine

2. Zhejiang University

3. Hangzhou

4. China

5. Department of Toxicology

6. School of Medicine

7. Department of Pharmaceutical Sciences

Abstract

Arsenic (+3 oxidation state) methyltransferase (AS3MT) contributes to induce the APL cell death by biotransformation of As₂O₃to more reactive methylated metabolites.

Funder

National Natural Science Foundation of China

Science and Technology Department of Zhejiang Province

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MT/C8MT00057C

Reference31 articles.

1. The Tribble with APL: A New Road to Therapy

2. Role of PML/RARα in the pathogenesis of APL

3. Acute Promyelocytic Leukemia: A Paradigm for Oncoprotein-Targeted Cure

4. Anticancer activity in human multiple myeloma U266 cells: synergy between cryptotanshinone and arsenic trioxide

5. Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

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