Effects of tris(1,3-dichloro-2-propyl)phosphate on pathomorphology and gene/protein expression related to thyroid disruption in rats-Reference-Cited by-同舟云学术

Effects of tris(1,3-dichloro-2-propyl)phosphate on pathomorphology and gene/protein expression related to thyroid disruption in rats

Published:2016 Issue:3 Volume:5 Page:921-930
ISSN:2045-452X
Container-title:Toxicology Research
language:en
Short-container-title:Toxicol. Res.

Author:

Zhao Fei¹²³⁴⁵,Wang Jing⁵⁶³⁴,Fang Yanjun⁵⁶³⁴,Ding Jia¹²³⁴,Yang Honglian⁵⁶³⁴,Li Li⁵⁶³⁴,Xi Zhuge⁵⁶³⁴,Qiao Haixuan¹²³⁴

Affiliation:

1. School of Biomedical Engineering and Technology

2. Tianjin Medical University

3. Tianjin

4. China

5. Tianjin Institute of Health and Environmental Medicine

6. A Key Laboratory of Risk Assessment & Control for Environment & Food Safety

Abstract

This study focused on the effects of TDCIPP on thyroid function and hormone homeostasis in mammals. Our results certified that TDCIPP induces slight thyroid follicular hyperplasia, disturbs the normal bioprocess on TH synthesis, biotransformation and hepatic detoxification of pubertal female SD rats, causing thyroid function disorder.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/TX/C5TX00374A

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