All-in-One digital microfluidics pipeline for proteomic sample preparation and analysis

Author:

Peng Jiaxi123,Chan Calvin1ORCID,Zhang Shuailong145ORCID,Sklavounos Alexandros A.12ORCID,Olson Maxwell E.1,Scott Erica Y.123,Hu Yechen123,Rajesh Vigneshwar1ORCID,Li Bingyu B.23,Chamberlain M. Dean1236,Zhang Shen78,Peng Hui19ORCID,Wheeler Aaron R.123ORCID

Affiliation:

1. Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada

2. Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON, M5S 3E1, Canada

3. Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON, M5S 3G9, Canada

4. School of Mechatronical Engineering, Beijing Institute of Technology, Beijing, 100081, China

5. Beijing Advanced Innovation Center for Intelligent Robots and Systems, Beijing Institute of Technology, Beijing, 100081, China

6. Saskatchewan Cancer Agency, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada

7. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada

8. Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, Hunan, 410000, China

9. School of Environment, University of Toronto, 33 Willcocks Street, Toronto, ON, M5S 3E8, Canada

Abstract

The All-in-One digital microfluidic pipeline allows for end-to-end automation of processing and analysis of mass-limited proteomic samples.

Funder

Natural Sciences and Engineering Research Council of Canada

Mitacs

Canada Research Chairs

Canada Foundation for Innovation

Ontario Research Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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