Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the SN2 substitution/condensation/tautomerization cascade process-Reference-Cited by-同舟云学术

Access to 6-hydroxy indolizines and related imidazo[1,5-a]pyridines through the SN2 substitution/condensation/tautomerization cascade process

Published:2021 Issue:41 Volume:11 Page:25624-25627
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Duan Guiyun¹²³⁴⁵,Liu Hao¹²³⁴⁵,Zhang Liqing¹²³⁴⁵,Yuan Chunhao¹²³⁴⁵^ORCID,Li Yongchao¹²³⁴⁵,Ge Yanqing¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pharmacy

2. Shandong First Medical University

3. Shandong Academy of Medical Sciences

4. Taian

5. P. R. China

Abstract

A simple and efficient cascade reaction was developed for the construction of hydroxy substituted indolizines from pyrrole-2-carbaldehydes and commercially available 4-halogenated acetoacetic esters.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA04425G

Reference44 articles.

1. Inhibitory activities of indolizine derivatives: a patent review

2. Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF–ElonginC interaction inhibitors

3. Functionalized spirooxindole-indolizine hybrids: Stereoselective green synthesis and evaluation of anti-inflammatory effect involving TNF-α and nitrite inhibition

4. Biological evaluation of indolizine-chalcone hybrids as new anticancer agents

5. Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists

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