Resistance and phylogeny guided discovery reveals structural novelty of tetracycline antibiotics-Reference-Cited by-同舟云学术

Resistance and phylogeny guided discovery reveals structural novelty of tetracycline antibiotics

Published:2022 Issue:43 Volume:13 Page:12892-12898
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Li Ling Yu¹,Hu Yi Ling¹,Sun Jia Lin¹,Yu Long Bo¹,Shi Jing¹,Wang Zi Ru¹,Guo Zhi Kai²,Zhang Bo¹,Guo Wen Jie¹,Tan Ren Xiang¹^ORCID,Ge Hui Ming¹^ORCID

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China

2. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Bio-technology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China

Abstract

Using resistance gene genome mining strategy and refinement with chain length factor, we obtained 25 distinct tetracycline biosynthetic gene clusters and a novel tetracycline. The biosynthesis of the highly modified tetracycline was investigated.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC03965F

Reference40 articles.

1. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork