Designed peptide-grafted hydrogels for human pluripotent stem cell culture and differentiation

Author:

Wang Ting1ORCID,Liu Qian1ORCID,Chang Yu-Tang2,Liu Jun1,Yu Tao1,Maitiruze Kailibinuer1,Ban Lee-Kiat3,Sung Tzu-Cheng1,Subbiah Suresh Kumar4,Renuka Remya Rajan4,Jen Shih Hsi5,Lee Henry Hsin-Chung367,Higuchi Akon128ORCID

Affiliation:

1. State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, No. 270, Xueyuan Road, Wenzhou, Zhejiang, 325027, China

2. Department of Chemical and Materials Engineering, National Central University, No. 300, Jhongda RD., Jhongli, Taoyuan, 32001, Taiwan

3. Department of Surgery, Hsinchu Cathay General Hospital, No. 678, Sec 2, Zhonghua Rd., Hsinchu, 30060, Taiwan

4. Centre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research, 173, Agaram Road, Tambaram East, Chennai-73, 600078, India

5. Department of Obstetrics and Gynecology, Taiwan Landseed Hospital, 77, Kuangtai Road, Pingjen City, Taoyuan 32405, Taiwan

6. Department of Surgery, Cathay General Hospital, Taipei, 10630, Taiwan

7. Graduate Institute of Translational and Interdisciplinary Medicine, National Central University, No. 300, Jhongda Rd., Jhongli, Taoyuan, 32001, Taiwan

8. R&D Center for Membrane Technology, Chung Yuan Christian University, Chungli, Taoyuan 320, Taiwan

Abstract

Human pluripotent stem cells cultured on several designed peptide-grafted hydrogels having a higher zeta potential show better proliferation and good differentiation into mesenchymal stem cells and osteoblasts.

Funder

Wenzhou Municipal Science and Technology Bureau

Landseed Hospital

Cathay General Hospital

State Key Laboratory of Ophthalmology

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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