Penicillin's catalytic mechanism revealed by inelastic neutrons and quantum chemical theory-Reference-Cited by-同舟云学术

Penicillin's catalytic mechanism revealed by inelastic neutrons and quantum chemical theory

Published:2013 Issue:47 Volume:15 Page:20447-20455
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Mucsi Zoltán¹,Chass Gregory A.²,Ábrányi-Balogh Péter³,Jójárt Balázs³,Fang De-Cai⁴,Ramirez-Cuesta Annibal J.⁵,Viskolcz Béla³,Csizmadia Imre G.¹

Affiliation:

1. Department of Chemistry, University of Toronto, Toronto, Ontario, M5S 3H6, Canada

2. School of Biological and Chemical Sciences, Queen Mary University of London, London, E1 4NS, UK

3. Department of Chemical Informatics University of Szeged, Szeged, H-6725, Hungary

4. College of Chemistry, Beijing Normal University, Beijing, 100875, China

5. ISIS Facility, STFC Rutherford Appleton Laboratory, Chilton, Didcot, Oxon OX11 0QX, UK

Abstract

Penicillin's dynamic structure–activity relationship resolved by inelastic neutrons kinetics, NMR and QM/MM-theory. Self-activating geometric changes catalyse bacterial enzyme inactivation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2013/CP/C3CP50868D

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4. Calicheamicin γ 1 I and DNA: Molecular Recognition Process Responsible for Site-Specificity

5. Shape-Dependent Catalysis: Insights into the Source of Catalysis for the CC-1065 and Duocarmycin DNA Alkylation Reaction

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