Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs-Reference-Cited by-同舟云学术

Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs

Published:2017 Issue:8 Volume:8 Page:5454-5459
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kueh Jui Thiang Brian¹²³⁴^ORCID,Stanley Nathan J.¹²³⁴^ORCID,Hewitt Russell J.¹²³⁴,Woods Laura M.¹²³⁴,Larsen Lesley¹²³⁴,Harrison Joanne C.⁵²³⁴^ORCID,Rennison David⁶⁷⁸⁴,Brimble Margaret A.⁶⁷⁸⁴^ORCID,Sammut Ivan A.⁵²³⁴^ORCID,Larsen David S.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Otago

3. Dunedin

4. New Zealand

5. Department of Pharmacology

6. School of Chemical Sciences

7. University of Auckland

8. Auckland

Abstract

A prodrug strategy for the release of the gasotransmitter carbon monoxide (CO) at physiological pH, based upon 3a-bromo-norborn-2-en-7-one Diels–Alder cycloadducts has been developed.

Funder

University of Otago

Ministry of Business, Innovation and Employment

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC01647F

Reference45 articles.

1. Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase-1

2. Heme Oxygenases in Cardiovascular Health and Disease