Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1-Reference-Cited by-同舟云学术

Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1

Published:2017 Issue:6 Volume:4 Page:1137-1144
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

He Yan¹²³⁴⁵^ORCID,Zheng Mengzhu¹²³⁴⁵,Li Qin¹²³⁴⁵,Hu Zhengxi¹²³⁴⁵^ORCID,Zhu Hucheng¹²³⁴⁵^ORCID,Liu Junjun¹²³⁴⁵,Wang Jianping¹²³⁴⁵,Xue Yongbo¹²³⁴⁵^ORCID,Li Hua¹²³⁴⁵,Zhang Yonghui¹²³⁴⁵^ORCID

Affiliation:

1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation

2. School of Pharmacy

3. Tongji Medical College

4. Huazhong University of Science and Technology

5. Wuhan 430030

Abstract

In silico screening of an in-house natural product database and confirmatory bioassays led to the identification of asperspiropene A (1) as an inhibitor of cancer-associated mutant IDH1.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/QO/C6QO00847J

Reference34 articles.

1. Anticancer compounds derived from fungal endophytes: their importance and future challenges

2. A New Golden Age of Natural Products Drug Discovery

3. Natural Products as Sources of New Drugs from 1981 to 2014