A ZIF-90 nanoplatform loaded with an enzyme-responsive organic small-molecule probe for imaging the hypoxia status of tumor cells-Reference-Cited by-同舟云学术

A ZIF-90 nanoplatform loaded with an enzyme-responsive organic small-molecule probe for imaging the hypoxia status of tumor cells

Published:2020 Issue:27 Volume:12 Page:14870-14881
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Zou Ruifen¹²³⁴⁵,Gong Qiuyu⁶⁷⁸,Shi Zhenzhi⁹¹⁰¹¹¹²,Zheng Jianping¹²³⁴⁵,Xing Jie¹²³⁴⁵,Liu Chuang¹²³⁴⁵,Jiang Zhenqi¹²³⁴⁵^ORCID,Wu Aiguo¹²³⁴⁵^ORCID

Affiliation:

1. Cixi Institute of Biomedical Engineering

2. Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Zhejiang Engineering Research Center for Biomedical Materials

3. Ningbo Institute of Materials Technology and Engineering

4. CAS

5. Ningbo 315201

6. School of Materials Science and Engineering

7. Nanyang Technological University

8. Singapore

9. The Research Institute of Advanced Technologies

10. Ningbo University

11. Ningbo 315211

12. China

Abstract

A new organic probe and a novel imaging system developed through loading the organic probe into ZIF-90@PEG were successfully synthesized for off–on fluorescence imaging via enzyme response to nitroreductase in vitro and in vivo.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Ningbo Municipal Bureau of Science and Technology

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/D0NR02580A

Reference48 articles.

1. Fluorescent markers for hypoxic cells

2. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

3. An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy

4. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

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