Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity-Reference-Cited by-同舟云学术

Lanthanide-based peptide biosensor to monitor CDK4/cyclin D kinase activity

Published:2017 Issue:45 Volume:53 Page:6109-6112
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

González-Vera Juan A.¹²³⁴⁵,Bouzada David⁶⁷⁸⁹,Bouclier Céline¹²³⁴⁵,Eugenio Vázquez M.⁶⁷⁸⁹^ORCID,Morris May C.¹²³⁴⁵^ORCID

Affiliation:

1. Institut des Biomolécules Max Mousseron

2. CNRS

3. IBMM-UMR 5247

4. Université de Montpellier

5. 15 Av. Charles Flahault

6. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica

7. Universidade de Santiago de Compostela

8. 15782 Santiago de Compostela

9. Spain

Abstract

We describe a lanthanide biosensor that responds to CDK4 kinase activity in melanoma cell extracts through a significant and dose dependent increase in luminescence, thanks to sensitization of a DOTA[Tb³⁺] complex incorporated into a CDK4 substrate peptide by a unique tryptophan residue in an adjacent phosphoaminoacid binding moiety.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC09948C

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