Kinetic characterization of an efficient cocaine hydrolase against toxic metabolites of cocaine-Reference-Cited by-同舟云学术

Kinetic characterization of an efficient cocaine hydrolase against toxic metabolites of cocaine

Published:2023 Issue:17 Volume:21 Page:3650-3659
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhan Max¹,Hou Shurong²,Shang Linyue¹²,Chen Xiabin²,Zhan Chang-Guo¹²^ORCID,Zheng Fang¹²

Affiliation:

1. Molecular Modeling and Biopharmaceutical Center, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, USA

2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, USA

Abstract

Combined molecular modeling, andin vitroandin vivoactivity assays have consistently demonstrated that enzyme E30-6, can efficiently hydrolyze not only cocaine itself, but also all of its toxic metabolites including cocaethylene and norcocaethylene formed in the presence of alcohol.

Funder

National Institute on Drug Abuse

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00374D

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4. Elevation of Extracellular Glutamate by Blockade of Astrocyte Glutamate Transporters Inhibits Cocaine Reinforcement in Rats via a NMDA-GluN2B Receptor Mechanism

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