Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase-Reference-Cited by-同舟云学术

Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase

Author:

Tysoe Christina R.¹²³⁴,Caner Sami⁵²³⁶,Calvert Matthew B.¹²³⁴,Win-Mason Anna¹²³⁴,Brayer Gary D.⁵²³⁶,Withers Stephen G.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of British Columbia

3. Vancouver BC

4. Canada V6T 1Z1

5. Department of Biochemistry and Molecular Biology

6. Canada V6T 1Z3

Abstract

Simplified analogues of montbretin A bind similarly to human alpha amylase and with nanomolar affinity.

Funder

National Institutes of Health

U.S. Department of Energy

Canadian Glycomics Network

Networks of Centres of Excellence of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

Reference23 articles.

1. World Health Organization , Global Report on Diabetes , 2006 , vol. 6

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