Simultaneous determination of ivabradine, metoprolol and their metabolites in rat plasma by ultra-performance liquid chromatography tandem mass spectrometry and its application in a pharmacokinetic study
Author:
Affiliation:
1. The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2. Wenzhou 325027
3. China
4. Ningbo Municipal Hospital of TCM
5. Ningbo 315010
Abstract
A sensitive and rapid UPLC-MS/MS method was developed to determine ivabradine, metoprolol and their corresponding metabolites in rat plasma simultaneously.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Engineering,General Chemical Engineering,Analytical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/AY/C5AY01657F
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