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Probing drug delivery and mechanisms of action in 3D spheroid cells by quantitative analysis

  • Published:2020 Issue:23 Volume:145 Page:7687-7694
  • ISSN:0003-2654
  • Container-title:The Analyst
  • language:en
  • Short-container-title:Analyst

Author:

Heo Chae Eun12345,Hong Areum12345,Kim Minji12345,Lee Jong Wha67894ORCID,Chae Soo Yeon12345,Sung Ki Woong101112134,Lee Ji Won101112134,Heo Sung Woo67894,Kim Hugh I.12345ORCID

Affiliation:

1. Department of Chemistry

2. Korea University

3. Seoul

4. Republic of Korea

5. Center for ProteoGenomics Research

6. Center for Analytical Chemistry

7. Division of Chemical and Medical Metrology

8. Korea Research Institute of Standards and Science (KRISS)

9. Daejeon 34113

10. Department of Pediatrics

11. Samsung Medical Center

12. Sungkyunkwan University School of Medicine

13. Seoul 06351

Abstract

A mass spectrometry (MS)-based quantitative approach is presented to investigate drug delivery and mechanism of action in 3D spheroid cells.

Funder

Korea Research Institute of Standards and Science

National Research Foundation of Korea

Korea University

Korea Basic Science Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry
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