Matrisomal components involved in regenerative wound healing in axolotl and Acomys: implications for biomaterial development

Author:

Avila-Martinez Nancy1,Gansevoort Merel1ORCID,Verbakel Juul1,Jayaprakash Haarshaadri23ORCID,Araujo Ines Maria34ORCID,Vitorino Marta234,Tiscornia Gustavo25,van Kuppevelt Toin H.1,Daamen Willeke F.1ORCID

Affiliation:

1. Department of Medical BioSciences, Radboud Research Institute, Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, The Netherlands

2. Centre of Marine Sciences (CCMAR), University of Algarve, 8005-139, Faro, Portugal

3. Faculty of Medicine and Biomedical Sciences (FMCB), University of Algarve, 8005-139, Faro, Portugal

4. Algarve Biomedical Center Research Institute (ABC-RI), University of Algarve, 8005-139, Faro, Portugal

5. Eugin Barcelona, Balmes, 236, 08006 Barcelona, Spain

Abstract

Acomys and axolotl share key regenerative components of the matrisome and glycosaminoglycan biosynthesis during scarless wound healing. Addition of key matrisomal components to biomaterials may improve skin wound healing in non-regenerating mammals.

Funder

H2020 Marie Skłodowska-Curie Actions

Radboud Universitair Medisch Centrum

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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