Cell-type-specific CRISPRization of mitochondrial DNA using bifunctional biodegradable silica nanoparticles-Reference-Cited by-同舟云学术

Cell-type-specific CRISPRization of mitochondrial DNA using bifunctional biodegradable silica nanoparticles

Published:2023 Issue:60 Volume:59 Page:9251-9254
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Jiang Linye¹,Zhou Bizhong¹,Qian Huijuan¹,Wang Hongfeng¹,Wang Yuxi¹,Fan Weijiao²,Zheng Guowan²,Ge Jingyan¹^ORCID

Affiliation:

1. Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China

2. Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, P. R. China

Abstract

By using biodegradable silica nanoparticles (BSNPs) with surface-modified triphenylphosphonium (TPP) and hyaluronic acid (HA), we report CRISPR/Cas9-mediated cell-type-specific mtDNA editing.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC01778H

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3. Efficient Mitochondrial Genome Editing by CRISPR/Cas9

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5. Mitochondria‐Targeted Gene Silencing Facilitated by Mito‐CPDs