Structural and morphological changes of breast cancer cells induced by iron(ii) complexes

Author:

Nel Janske1,Siniscalco David2,Hognon Cécilia3,Bouché Mathilde4,Touche Nadége5ORCID,Brunner Émilie5,Gros Philippe C.4ORCID,Monari Antonio36ORCID,Grandemange Stéphanie5,Francius Grégory2ORCID

Affiliation:

1. Université de Lorraine, LIBio, F-54000, Nancy, France

2. Université de Lorraine and CNRS, LPCME UMR 7564, F-54000 Nancy, France

3. Université de Lorraine and CNRS, LPCT UMR 7019, F-54000 Nancy, France

4. Université de Lorraine and CNRS, L2CM UMR 7053, F-54000, Nancy, France

5. Université de Lorraine and CNRS, CRAN UMR 7039, F-54000 Nancy, France

6. Université de Paris, ITODYS, CNRS, F-75006, Paris, France

Abstract

Iron(ii)-based complexes were able to penetrate into the cytoplasm without disrupting the cell membrane. The complexes induced size, morphological, stiffness and cytoarchitectural changes in both triple negative breast cancer and normal cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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