Design of dual MMP-2/HDAC-8 inhibitors by pharmacophore mapping, molecular docking, synthesis and biological activity-Reference-Cited by-同舟云学术

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Design of dual MMP-2/HDAC-8 inhibitors by pharmacophore mapping, molecular docking, synthesis and biological activity

Published:2015 Issue:88 Volume:5 Page:72373-72386
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Halder Amit K.¹²³⁴⁵,Mallick Sumana⁶⁷⁵⁸,Shikha Deep¹²³⁴⁵,Saha Achintya⁹¹⁰¹¹⁸,Saha Krishna D.⁶⁷⁵⁸,Jha Tarun¹²³⁴⁵

Affiliation:

1. Natural Science Laboratory

2. Division of Medicinal and Pharmaceutical Chemistry

3. Department of Pharmaceutical Technology

4. Jadavpur University

5. Kolkata 700032

6. Cancer Biology & Inflammatory Disorder Division

7. CSIR-Indian Institute of Chemical Biology

8. India

9. Department of Chemical Technology

10. University of Calcutta

11. Kolkata 700009

Abstract

Recent analyses have highlighted the promotion of cancer migration and invasion, mediated through HDAC via MMP-2 and MMP-9.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA12606A

Reference53 articles.

1. Matrix metalloproteinases: Fold and function of their catalytic domains

2. Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

3. Synthesis and Structure−Activity Relationships of 4-alkynyloxy Phenyl Sulfanyl, Sulfinyl, and Sulfonyl Alkyl Hydroxamates as Tumor Necrosis Factor-α Converting Enzyme and Matrix Metalloproteinase Inhibitors

4. Matrix metalloproteinases (MMPs): Chemical–biological functions and (Q)SARs

5. V. Vargova , M.Pytliak and V.Mechirova, in Matrix metalloproteanases, ed. S. P. Gupta, Springer, Basel, 1st edn, 2012, ch. 4, pp. 1–33

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