Oral bomb effect nanotherapeutics alleviate ulcerative colitis through coordinated anti-inflammatory and pro-resolving strategies-Reference-Cited by-同舟云学术

Oral bomb effect nanotherapeutics alleviate ulcerative colitis through coordinated anti-inflammatory and pro-resolving strategies

Published:2024 Issue: Volume: Page:
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Yang Mei¹²^ORCID,Zhu Yuanyuan³,Wei Xiaodan¹²,Feng Jinteng¹²,He Yingli⁴,Jiang Jue⁵,Zhou Qi⁵,Zhang Mingzhen³^ORCID,Zhang Guangjian¹²,Ma Wenqi⁵

Affiliation:

1. Department of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China

2. Key Laboratory of Enhanced Recovery After Surgery of Integrated Chinese and Western Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China

3. School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi, China

4. Department of Infectious Diseases, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China

5. Department of Medical Ultrasound, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China

Abstract

Orally nano-bomb system with siCD98 and Ac2-26 alleviates ulcerative colitis via anti-inflammatory and pro-resolving, reduces pro-inflammatory cytokine expression, restores intestinal barrier function and promotes M1 to M2 macrophage polarization.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D4BM00843J

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