A dendritic polyamidoamine supramolecular system composed of pillar[5]arene and azobenzene for targeting drug-resistant colon cancer

Author:

Liu Hongyu12,Yang Jie3,Yan Xiangjie2,Li Chaoqi2,Elsabahy Mahmoud4,Chen Li1,Yang Ying-Wei3ORCID,Gao Hui12ORCID

Affiliation:

1. State Key Laboratory of Separation Membranes and Membrane Processes, School of Materials Science and Engineering, Tiangong University, Tianjin 300387, P. R. China

2. Tianjin Key Laboratory of Drug Targeting and Bioimaging, Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China

3. International Joint Research Laboratory of Nano-Micro Architecture Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China

4. Science Academy, School of Biotechnology, Badr University in Cairo, Badr City, Cairo 11829, Egypt

Abstract

A smart supramolecular quaternary ammonium nanoparticle, namely quaternary ammonium PAMAM-AZO@CP[5]A (Q-P-A@CP[5]A) was designed to treat drug-resistant colorectal cancer (CRC) caused by Fusobacterium nucleatum.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Tianjin Municipal Science and Technology Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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