A β-carboline derivative-based nickel(ii) complex as a potential antitumor agent: synthesis, characterization, and cytotoxicity-Reference-Cited by-同舟云学术

A β-carboline derivative-based nickel(ii) complex as a potential antitumor agent: synthesis, characterization, and cytotoxicity

Published:2018 Issue:1 Volume:9 Page:100-107
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Yang Jing-Mei¹²³⁴⁵,Zhu Yan-Hong¹²³⁴⁵,Chen Sheng¹²³⁴⁵,Lu Xing¹²³⁴⁵,Wu Yi-Ming¹²³⁴⁵,Ma Feng-E¹²³⁴⁵,Li Liang-Ping¹²³⁴⁵,Yang Yang¹²³⁴⁵,Shi Zhen-Hao¹²³⁴⁵,Huang Kun-Yuan¹²³⁴⁵,Hong Xue¹²³⁴⁵,Jiang Ping⁶⁷⁸⁹¹⁰,Peng Yan¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources

2. School of Chemistry and Pharmacy

3. Guangxi Normal University

4. Guilin 541004

5. China

6. Shanghai Mental Health Center

7. Shanghai Institute of Mental Health

8. Shanghai Jiao Tong University School of Medicine

9. Shanghai 200030

10. P.R. China

Abstract

A novel nickel(ii) complex was synthesized and characterized. It significantly induced cell cycle arrest at S phase, and caused the down-regulation of p-AKT, cyclin E, cyclin A and CDK2 and the up-regulation of p27.

Funder

Natural Science Foundation of Guangxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C7MD00428A

Reference64 articles.

1. Charles F. Kettring prize. Fundamental studies with cisplatin

2. Structure, Cytotoxicity, and DNA-Cleavage Properties of the Complex [CuII(pbt)Br2]

3. Thermal unfolding of a group I ribozyme: the low-temperature transition is primarily disruption of tertiary structure

4. Targeting and delivery of platinum-based anticancer drugs

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