Cm3+/Eu3+induced structural, mechanistic and functional implications for calmodulin-Reference-Cited by-同舟云学术

Cm3+/Eu3+induced structural, mechanistic and functional implications for calmodulin

Published:2019 Issue:38 Volume:21 Page:21213-21222
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Drobot Björn¹²³⁴^ORCID,Schmidt Moritz¹²³⁴^ORCID,Mochizuki Yuji⁵⁶⁷⁸⁹^ORCID,Abe Takaya⁵⁶⁷⁸,Okuwaki Koji⁵⁶⁷⁸^ORCID,Brulfert Florian¹⁰¹¹¹²¹³¹⁴,Falke Sven¹⁵¹⁶¹⁷⁴^ORCID,Samsonov Sergey A.¹⁸¹⁹²⁰²¹^ORCID,Komeiji Yuto²²²³²⁴⁸^ORCID,Betzel Christian¹⁵¹⁶¹⁷⁴^ORCID,Stumpf Thorsten¹²³⁴,Raff Johannes¹²³⁴^ORCID,Tsushima Satoru¹²³⁴²⁵^ORCID

Affiliation:

1. Institute of Resource Ecology

2. Helmholtz-Zentrum Dresden-Rossendorf (HZDR)

3. Dresden

4. Germany

5. Department of Chemistry and Research Center for Smart Molecules

6. Rikkyo University

7. Tokyo

8. Japan

9. Institute of Industrial Science

10. Institut de Physique Nucléaire d'Orsay

11. CNRS-IN2P3

12. Université Paris-Sud

13. Université Paris-Saclay

14. Orsay

15. Laboratory for Structural Biology of Infection and Inflammation c/o DESY

16. Universität Hamburg

17. Hamburg

18. Department of Chemistry

19. University of Gdańsk

20. Gdańsk

21. Poland

22. Biomedical Research Institute

23. National Institute of Advanced Industrial Science and Technology (AIST)

24. Tsukuba

25. Tokyo Tech World Research Hub Initiative (WRHI)

Abstract

Trivalent lanthanide and actinide can strongly bind to calmodulin (CaM). The global structure of Ln/An-bound CaM were found to be similar to Ca-CaM but the local environment around Ln/An is distorted giving less structural rigidity to Ln/An-CaM.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Narodowe Centrum Nauki

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CP/C9CP03750K

Reference89 articles.

1. Ion channels and calcium signaling in motile cilia